Overview
Orgovyx is approved by the U.S. Food and Drug Administration (FDA) for the treatment of advanced prostate cancer in adults. It is used as a form of androgen deprivation therapy (ADT) to reduce the levels of testosterone, which prostate cancer cells need to grow. Orgovyx is also known by its drug name, relugolix.

Orgovyx is a gonadotropin-releasing hormone (GnRH) receptor antagonist. It works by directly blocking the GnRH receptor in the pituitary gland, leading to a rapid decrease in the production of testosterone without the initial hormone surge that occurs with other types of ADT.

How do I take it?
Prescribing information states that Orgovyx is taken by mouth as a tablet once daily at about the same time each day. The first dose is a higher loading dose, followed by a lower daily dose. The tablets should be swallowed whole and not crushed or chewed. Orgovyx can be taken with or without food. The drug should be taken exactly as prescribed by a healthcare provider.

Side effects
Common side effects of Orgovyx include hot flushes, increased blood glucose, increased triglycerides (a type of fat in the blood), musculoskeletal pain, decreased hemoglobin (a protein in red blood cells), increased liver enzymes, fatigue, constipation, and diarrhea.

Rare but serious side effects may include QT interval prolongation (a heart rhythm disorder), hypersensitivity reactions such as angioedema (swelling under the skin), and embryo-fetal toxicity (potential harm to an unborn baby). People taking Orgovyx should be advised to use effective contraception if they have partners who may become pregnant.

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Label: Orgovyx — Relugolix Tablet, Film Coated — DailyMed